Acylated triterpenoidal saponins and cytokinins from Gleditsia aquatica

Ehab A. Ragab; Mohammed Hosny; Hazem A. Kadry; Hassan A. Ammar

Acylated triterpenoidal saponins and cytokinins from Gleditsia aquatica

Ehab A. Ragab, Mohammed Hosny, Hazem A. Kadry, Hassan A. Ammar

Surgery

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7 Citations (Scopus)

Abstract

Two new bisdesmosidic triterpenoidal saponins acylated with one and two monoterpenoid units; aquaticoside A and B (1 and 2), two new cytokinins, aquaticine A and B (3 and 4), and one known cytokinin; adenosine (5), were isolated from the fruits of Gleditsia aquatica. Their structures were established by means of extensive 1D and 2D NMR studies and chemical degradation. Cytotoxicities (ED₅₀) of various extracts and isolated pure saponins (1 and 2), were measured against various tumor cell lines. The isolated pure saponins (1 and 2), showed the most potent cytotoxicities with ovary adenocarcinoma (MDAH 2774, NIH: OVCAR-3), uterus mesodermal tumor (SK-UT-1), skin malignant melanoma (G-361) and colon colorectal adenocarcinoma (LS 174 T) cell lines.

Original language	English
Pages (from-to)	24-33
Number of pages	10
Journal	Journal of Pharmacognosy and Phytotherapy
Volume	2
Issue number	3
Publication status	Published - 2010

Keywords

Acylated triterpenoidal saponins
Cytokinins
Gleditsia aquatica
NMR

ASJC Scopus subject areas

Drug Discovery

Cite this

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abstract = "Two new bisdesmosidic triterpenoidal saponins acylated with one and two monoterpenoid units; aquaticoside A and B (1 and 2), two new cytokinins, aquaticine A and B (3 and 4), and one known cytokinin; adenosine (5), were isolated from the fruits of Gleditsia aquatica. Their structures were established by means of extensive 1D and 2D NMR studies and chemical degradation. Cytotoxicities (ED50) of various extracts and isolated pure saponins (1 and 2), were measured against various tumor cell lines. The isolated pure saponins (1 and 2), showed the most potent cytotoxicities with ovary adenocarcinoma (MDAH 2774, NIH: OVCAR-3), uterus mesodermal tumor (SK-UT-1), skin malignant melanoma (G-361) and colon colorectal adenocarcinoma (LS 174 T) cell lines.",

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T1 - Acylated triterpenoidal saponins and cytokinins from Gleditsia aquatica

AU - Ragab, Ehab A.

AU - Hosny, Mohammed

AU - Kadry, Hazem A.

AU - Ammar, Hassan A.

PY - 2010

Y1 - 2010

N2 - Two new bisdesmosidic triterpenoidal saponins acylated with one and two monoterpenoid units; aquaticoside A and B (1 and 2), two new cytokinins, aquaticine A and B (3 and 4), and one known cytokinin; adenosine (5), were isolated from the fruits of Gleditsia aquatica. Their structures were established by means of extensive 1D and 2D NMR studies and chemical degradation. Cytotoxicities (ED50) of various extracts and isolated pure saponins (1 and 2), were measured against various tumor cell lines. The isolated pure saponins (1 and 2), showed the most potent cytotoxicities with ovary adenocarcinoma (MDAH 2774, NIH: OVCAR-3), uterus mesodermal tumor (SK-UT-1), skin malignant melanoma (G-361) and colon colorectal adenocarcinoma (LS 174 T) cell lines.

AB - Two new bisdesmosidic triterpenoidal saponins acylated with one and two monoterpenoid units; aquaticoside A and B (1 and 2), two new cytokinins, aquaticine A and B (3 and 4), and one known cytokinin; adenosine (5), were isolated from the fruits of Gleditsia aquatica. Their structures were established by means of extensive 1D and 2D NMR studies and chemical degradation. Cytotoxicities (ED50) of various extracts and isolated pure saponins (1 and 2), were measured against various tumor cell lines. The isolated pure saponins (1 and 2), showed the most potent cytotoxicities with ovary adenocarcinoma (MDAH 2774, NIH: OVCAR-3), uterus mesodermal tumor (SK-UT-1), skin malignant melanoma (G-361) and colon colorectal adenocarcinoma (LS 174 T) cell lines.

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KW - Cytokinins

KW - Gleditsia aquatica

KW - NMR

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Acylated triterpenoidal saponins and cytokinins from Gleditsia aquatica

Abstract

Keywords

ASJC Scopus subject areas

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