Acylated triterpenoidal saponins and cytokinins from Gleditsia aquatica

Ehab A. Ragab, Mohammed Hosny, Hazem A. Kadry, Hassan A. Ammar

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7 Citations (Scopus)


Two new bisdesmosidic triterpenoidal saponins acylated with one and two monoterpenoid units; aquaticoside A and B (1 and 2), two new cytokinins, aquaticine A and B (3 and 4), and one known cytokinin; adenosine (5), were isolated from the fruits of Gleditsia aquatica. Their structures were established by means of extensive 1D and 2D NMR studies and chemical degradation. Cytotoxicities (ED50) of various extracts and isolated pure saponins (1 and 2), were measured against various tumor cell lines. The isolated pure saponins (1 and 2), showed the most potent cytotoxicities with ovary adenocarcinoma (MDAH 2774, NIH: OVCAR-3), uterus mesodermal tumor (SK-UT-1), skin malignant melanoma (G-361) and colon colorectal adenocarcinoma (LS 174 T) cell lines.

Original languageEnglish
Pages (from-to)24-33
Number of pages10
JournalJournal of Pharmacognosy and Phytotherapy
Issue number3
Publication statusPublished - 2010


  • Acylated triterpenoidal saponins
  • Cytokinins
  • Gleditsia aquatica
  • NMR

ASJC Scopus subject areas

  • Drug Discovery


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