New Sulfur-Containing Diketopiperazine from Marine-Derived Bacteria Streptomyces rochei sp. 81 with Potent Carbonic Anhydrase II Inhibition

Ahmed N. Al-Rawahi, Raeid M.M. Abed, Najeeb Ur Rehman*, Kashif Rafiq, Ajmal Khan, Abdul L. Khan, Majid Khan, Sobia Ahsan Halim, Fahad Al-Senafi, Huda Mahmoud, Ahmed Al-Harrasi*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء


The ethyl acetate extract of the marine bacterial strain Streptomyces rochei sp. 81 was purified by silica gel column chromatography to obtain three diketopiperazines (1–3) and one straight chain fatty acid (4). The compounds were identified as cyclo(L-leu-N-ethenethiol-L-pro) (1), cyclo(L-Leu-L-Pro) (2), cyclo(L-Pro-D-Tyr) (3), and 2,4-dimethyldocasonoic acid (4) by HR-ESI-MS and NMR techniques. One new (1) and three known compounds (2–4) were screened for carbonic anhydrase-II (CA-II) inhibition and as a result 1 and 3 were found to be the most active compounds with IC50 of 9.8 ± 0.56 and 10.9 ± 0.88 μM, respectively. The results indicated that these two compounds (1 and 3) can be promising candidates for anticancer drugs.

اللغة الأصليةEnglish
دوريةChemistry of Natural Compounds
المعرِّفات الرقمية للأشياء
حالة النشرAccepted/In press - 2023
منشور خارجيًانعم

ASJC Scopus subject areas

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